Download e-book for kindle: A Practical Guide to Rational Drug Design by Sun Hongmao

By Sun Hongmao

This booklet will not be an exhaustive survey masking all features of rational drug layout. as an alternative, it's going to supply severe information via real-world examples. correct case stories could be offered and analyzed to demonstrate the subsequent: tips to optimize a lead compound even if one has excessive or low degrees of structural info; find out how to derive hits from rivals’ energetic compounds or from typical ligands of the pursuits; the right way to springboard from rivals’ SAR wisdom in lead optimization; the best way to layout a ligand to intervene with protein-protein interactions by means of effectively interpreting the PPI interface; the way to steer clear of IP blockage utilizing facts mining; how you can build and entirely make the most of a knowledge-based molecular descriptor method; find out how to construct a competent QSAR version by way of concentrating on info caliber and correct number of molecular descriptors and statistical techniques. A sensible advisor to Rational Drug Design makes a speciality of computational drug layout, with purely simple insurance of biology and chemistry matters, comparable to assay layout, aim validation and artificial routes.

  • Discusses various tactics appropriate to day-by-day drug layout
  • Readers can obtain the fabrics utilized in the booklet, together with buildings, scripts, uncooked information, protocols, and codes, making this booklet appropriate source for brief classes or workshops
  • Offers a different standpoint on drug discovery study a result of author’s cross-discipline schooling background 
  • Explores the author’s wealthy reviews in either pharmaceutical and educational settings

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A Practical Guide to Rational Drug Design by Sun Hongmao


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